房建凯 副教授
时间: 2022-01-04  作者:   浏览次数: 90


房建凯,苏州大学副教授,硕士生导师。20136月于苏州大学护理学院取得护理学本科学位;20166月于苏州大学基础医学与生物科学学院取得病理学与病理生理学硕士学位,并荣获苏州大学“优秀毕业研究生”称号;20206月于苏州大学天降艳福不是福取得病理学与病理生理学博士学位,并荣获苏州大学“优秀毕业研究生”称号;20207月留院师从时玉舫院士从事博士后研究,并于20238月荣获“优秀”出站考评等第。20239月起任苏州大学天降艳福不是福副教授。先后主持国家自然科学基金青年基金1项,参与国家重点研发计划课题2项。

邮箱:jkfang@suda.edu.cn

通讯地址:

苏州市工业园区仁爱路199号苏州大学4033103

研究方向:

探索炎症微环境中干细胞对重大疾病(自身免疫性疾病、纤维化和肿瘤等)发生发展的调控作用及干预策略。主要研究方向:(1)疾病演进过程中内源性原住干细胞群体和外源性移植干细胞群体受炎症微环境调控的异同点;(2)炎症微环境中调控干细胞参与免疫调节和组织修复的关键免疫细胞和炎症因子;(3)受炎症微环境调控的干细胞其代谢状态的改变在决定自身免疫调节功能和组织修复能力中的作用和机制。

在研项目:

1国家自然科学基金委员会青年科学基金项目、82202032NAD+代谢编程间充质干细胞免疫调控功能的作用机制与优化策略研究、2023-01-012025-12-3130万元、在研、主持

2国家科学技术部重点研发计划专项、2021YFA1100600、牙颌组织发育与再生中颅颌干细胞谱系分化及其微环境调控、2021-122026-062529.4万元、在研、参与

3国家科学技术部重点研发计划专项、2022YFA0807300、组织器官发育与稳态维持的关键脂质代谢物及其调控网络、2022-122027-112568万元,在研,参与

研究论文:(#共同第一作者,*通讯作者)

1.Fang Jiankai; Hou Pengbo; Liu Shisong; Zuo Muqiu; Liu Zhanhong; Chen Wangwang; Han Yuyi; Li Yanan; Wang Tingting; Feng Chao; Li Peishan; Shao Changshun*; Shi Yufang*; NAD+ salvage governs the immunosuppressive capacities of mesenchymal stem cells, Cellular & Molecular Immunology, 2023, 20(10): 1171-1185.

2. Fang, Jiankai#; Chen, Wangwang#; Hou, Pengbo; Liu, Zhanhong; Zuo, Muqiu; Liu Shisong; Feng, Chao; Han, Yuyi; Li Peishan*; Shi, Yufang*; Shao, Changshun*; NAD+ metabolism-based immunoregulation and therapeutic potential, Cell & Bioscience, 2023, 13(1): 81.

3. Fang, Jiankai#; Feng, Chao#; Chen, Wangwang; Hou, Pengbo; Liu, Zhanhong; Zuo, Muqiu; Han, Yuyi; Xu, Chenchang; Melino, Gerry; Verkhratsky, Alexei; Wang, Ying; Shao, Changshun*; Shi, Yufang*; Redressing the interactions between stem cells and immune system in tissue regeneration, Biology Direct, 2021, 16(1): 18.

4.Fang Jiankai#; Zhang Shengchao#; Liu Zhanhong; Pan Yongsha; Cao Lijuan; Hou Pengbo; Chen Yongjing; Zhang Yuyan; Li Xiaolei; Liu Rui; Shang Qianwen; Zheng Zhiyuan; Song Lin; Li Yanan; Fu Zhonglin; Lin Liangyu; Melino Gerry; Wang Ying; Shao Changshun*; Shi Yufang*; Skeletal muscle stem cells confer maturing macrophages anti-inflammatory properties through IGF-2, Stem Cells Translational Medicine, 2020, 9(7): 773-785.

5. Fang, Jiankai#; Chen, Liang#; Lu, Xueguan; Cao, Dan; Guo, Lingling; Zhang, Yongsheng; Li, Liubing; Zhang, Lifeng; Kuang, Yuting*; Wang, Shouli*; Optimization of transforming growth factor-beta 1 siRNA loaded chitosan-tripolyphosphate nanoparticles for the treatment of colorectal cancer hepatic metastasis in a mouse model, Journal of Biomedical Nanotechnology, 2016, 12(7): 1489-1500.

6. Zhang, Shengchao#; Fang, Jiankai#; Liu, Zhanhong; Hou, Pengbo; Cao, Lijuan; Zhang, Yuyan; Liu, Rui; Li, Yanan; Shang, Qianwen; Chen, Yongjing; Feng, Chao; Wang, Guan; Melino, Gerry; Wang, Ying; Shao, Changshun*; Shi, Yufang*; Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis, Stem Cell Research & Therapy, 2021, 12(1): 50.

7. Zuo Muqiu#; Fang Jiankai#; Huang Peiqing; Liu Shisong; Hou Pengbo; Wang Shiqing; Liu Zhanhong; Feng Chao; Cao Lijuan; Li Peishan; Shi Yufang*; Shao Changshun*; IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells, Cell Death Discovery, 2023, 9(1): 269.   

8. Wang, Ying; Fang, Jiankai; Liu, Benming; Shao, Changshun; Shi, Yufang*; Reciprocal regulation of mesenchymal stem cells and immune responses, Cell Stem Cell, 2022, 29(11): 1515-1530.

9. Hou, Pengbo; Fang, Jiankai; Liu, Zhanhong; Shi, Yufang; Agostini, Massimiliano; Bernassola, Francesca; Bove, Pierluigi; Candi, Eleonora; Rovella, Valentina; Sica, Giuseppe; Sun Qiang; Wang, Ying; Scimeca, Manuel; Federici, Massimo*; Mauriello, Alessandro*; Melino, Gerry*; Macrophage polarization and metabolism in atherosclerosis, Cell Death & Disease, 2023, 14(10): 691.

10. Han, Yuyi; Yang, Jianxin; Fang, Jiankai; Zhou, Yipeng; Candi, Eleonora; Wang, Jihong; Hua, Dong; Shao, Changshun*; Shi, Yufang*; The secretion profile of mesenchymal stem cells and potential applications in treating human diseases, Signal Transduction & Targeted Therapy, 2022, 7(1): 92.

11. Liu, Zhanhong; Hou, Pengbo; Fang Jiankai; Zhu, Jingyu; Zha, Juanmin; Liu, Rui; Ding, Yayun; Zuo, Muqiu; Li, Peishan; Cao, Lijuan; Feng, Chao; Melino, Gerry; Shao, Changshun*; Shi, Yufang*; Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan, Oncogene, 2023, 42(44): 3221-3235.

12. Li, Yanan; Giovannini, Sara; Wang, Tingting; Fang, Jiankai; Li, Peishan; Shao, Changshun; Wang, Ying; TOR centre; Shi, Yufang*; Candi, Eleonora*; Melino, Gerry*; Bernassola, Francesca*; p63: a crucial player in epithelial stemness regulationOncogene, 2023, 42(46): 3371-3384.

13. Li, Xiaolei; Su, Xiao; Liu, Rui; Pan, Yongsha; Fang, Jiankai; Cao, Lijuan; Feng, Chao; Shang, Qianwen; Chen, Yongjing; Shao, Changshun*; Shi, Yufang*; HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression, Oncogene, 2021, 40(10): 1836-1850.