蔡桓 副教授(特聘)
时间: 2022-01-05  作者:   浏览次数: 132

  

蔡桓,苏州大学青年特聘教授、硕士研究生导师。2020年于丹麦哥本哈根大学获生物医学博士学位,2020年至2023在瑞典卡罗林斯卡医学院血液和再生医学研究所从事博士后研究。欧洲自由基学会和英国基质生物学会会员,瑞典获Incyte北欧血液学研究基金(2021)和KI研究基金(2022)资助。202310月起任职苏州大学天降艳福不是福。

邮箱:huancai@suda.edu.cn

通讯地址:苏州市工业园区仁爱路199号苏州大学4033209

研究方向:

主要从事胞外基质微环境相关研究,致力于从代谢、氧化等层面探究间充质干细胞及其分泌的细胞因子、基质蛋白等微环境组分在急性髓系白血病和实体肿瘤等疾病进程中的作用及机制,期待为相关疾病预防和治疗提供新的潜在作用靶点。

代表性研究论文:(#共同第一作者,*通讯作者)

1. Cai, H.#, M. Kondo#, L. Sandhow, P. Xiao, A. S. Johansson, T. Sasaki, J. Zawacka-Pankau, K. Tryggvason, J. Ungerstedt, J. Walfridsson, M. Ekblom, and H. Qian*. "Critical Role of Lama4 for Hematopoiesis Regeneration and Acute Myeloid Leukemia Progression." Blood 139, no. 20 (May 19 2022): 3040-57.封面文章


2. Dolinska, M.#, Cai, H.# A. Mansson#, J. Shen, P. Xiao, T. Bouderlique, X. Li, E. Leonard, M. Chang, Y. Gao, J. P. Medina, M. Kondo, L. Sandhow, A. S. Johansson, S. Deneberg, S. Soderlund, M. Jadersten, J. Ungerstedt, M. Tobiasson, A. Ostman, S. Mustjoki, L. Stenke, K. Le Blanc, E. Hellstrom-Lindberg, S. Lehmann, M. Ekblom, U. Olsson-Stromberg, M. Sigvardsson, and H. Qian*. "Characterization of the Bone Marrow Niche in Patients with Chronic Myeloid Leukemia Identifies Cxcl14 as a New Therapeutic Option." Blood 142, no. 1 (Jul 6 2023): 73-89.


3. Cai, H., C. Y. Chuang, S. Vanichkitrungruang, C. L. Hawkins, and M. J. Davies*. "Hypochlorous Acid-Modified Extracellular Matrix Contributes to the Behavioral Switching of Human Coronary Artery Smooth Muscle Cells." Free Radic Biol Med 134 (Apr 2019): 516-26.


4. Sandhow, L., Cai, H, E. Leonard, P. Xiao, L. Tomaipitinca, A. Mansson, M. Kondo, X. Sun, A. S. Johansson, K. Tryggvason, M. Kasper, M. Jaras, and H. Qian. "Skin Mesenchymal Niches Maintain and Protect Aml-Initiating Stem Cells." J Exp Med 220, no. 10 (Oct 2 2023).


5. Cai, H.#, Y. Jiang#, S. Zhang, N. N. Cai, W. Q. Zhu, R. Yang, B. Tang, Z. Y. Li, and X. M. Zhang*. "Culture Bovine Prospermatogonia with 2i Medium." Andrologia 53, no. 6 (Jul 2021): e14056.


6. Cai, H., B. Tang, J. Y. Wu, X. X. Zhao, Z. Z. Wang, X. L. An, L. X. Lai, Z. Y. Li, and X. M. Zhang*. "Enrichment and in Vitro Features of the Putative Gonocytes from Cryopreserved Testicular Tissue of Neonatal Bulls." Andrology 4, no. 6 (Nov 2016): 1150-58.


7. Cai, H.#, J. Y. Wu#, X. L. An, X. X. Zhao, Z. Z. Wang, B. Tang, Z. P. Yue, Z. Y. Li, and X. M. Zhang*. "Enrichment and Culture of Spermatogonia from Cryopreserved Adult Bovine Testis Tissue." Anim Reprod Sci 166 (Mar 2016): 109-15.


8. Nybo, T., Cai, H. C. Y. Chuang, L. F. Gamon, A. Rogowska-Wrzesinska, and M. J. Davies*. "Chlorination and Oxidation of Human Plasma Fibronectin by Myeloperoxidase-Derived Oxidants, and Its Consequences for Smooth Muscle Cell Function." Redox Biol 19 (Oct 2018): 388-400.


9. Shu, N., P. Hagglund, Cai, H., C. L. Hawkins, and M. J. Davies*. "Modification of Cys Residues in Human Thioredoxin-1 by P-Benzoquinone Causes Inhibition of Its Catalytic Activity and Activation of the Ask1/P38-Mapk Signalling Pathway." Redox Biol 29 (Jan 2020): 101400.


10. Zhang, X. M., S. Anwar, Y. Kim, J. Brown, I. Comte, Cai, H., N. N. Cai, R. Wade-Martins, and F. G. Szele*. "The A30p Alpha-Synuclein Mutation Decreases Subventricular Zone Proliferation." Hum Mol Genet 28, no. 14 (Jul 15 2019): 2283-94.