邵常顺 教授
时间: 2022-01-07  作者:   浏览次数: 3452

邵常顺,苏州大学特聘教授、博士生导师。获美国印第安纳大学博士学位。曾任罗格斯大学副教授、山东大学教授、实验畸形学教育部重点实验室主任等职。现任Frontiers in Oncology副主编、Mutation Res等杂志编委。承担过多项国家自然科学基金和科技部课题。累计发表SCI论文160余篇,引用超过15000Google Scholar)。以第一或通讯作者在Aging CellCancer ResCell Mol ImmunolJ Cell Biol Nature GenetNature CommunOncogenePNASRedox Biol等杂志发表SCI论文60余篇。

邮箱:shaoc@suda.edu.cn

研究方向:活性氧对细胞命运及功能的调控作用、细胞衰老与组织再生、干细胞与免疫微环境交互调控

承担项目:

1. 国家自然科学基金(32150710523),2022/01-2023/12160万元,项目负责人

2. 国家重点研发计划干细胞研究与器官修复专项(2021YFA1100602),2021/12-2026/06,课题负责人(586万元)

代表性研究论文:(#共同第一作者,*通讯作者 

1. Fang J, Hou P, Liu S, Zuo M, Liu Z, Chen W, Han Y, Li Y, Wang T, Feng C, Li P, Shao C*, Shi Y*. NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells. Cell Mol Immunol. 2023 Aug 14. doi: 10.1038/s41423-023-01073-2. Epub ahead of print. PMID: 37580400.

2. Zuo M, Fang J, Huang P, Liu S, Hou P, Wang S, Liu Z, Feng C, Cao L, Li P, Shi Y*, Shao C*. IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells. Cell Death Discov. 2023 Jul 28;9(1):269. doi: 10.1038/s41420-023-01568-x. PMID: 37507432; PMCID: PMC10382538.

3. Li P, Ou Q, Shi S*, Shao C*. Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications. Cell Mol Immunol. 2023 Jun;20(6):558-569. doi: 10.1038/s41423-023-00998-y. Epub 2023 Mar 27. PMID: 36973490; PMCID: PMC10040934.

4. Wang Z, Wang S, Qin J, Zhang X, Lu G, Liu H, Guo H, Wu L, Shender VO, Shao C*, Kong B*, Liu Z*. Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12. Nat Commun. 2022 Oct 21;13(1):6246. doi: 10.1038/s41467-022-34042-w. PMID: 36271053; PMCID: PMC9587234.

5. Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J, Hua D, Shao C*, Shi Y*. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther. 2022 Mar 21;7(1):92. doi: 10.1038/s41392-022-00932-0. PMID: 35314676; PMCID: PMC8935608.

6. Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y, Shao C*. Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress. Oncogene. 2022 Jan;41(3):427-443. doi: 10.1038/s41388-021-02105-9. Epub 2021 Nov 12. PMID: 34773075; PMCID: PMC8755538.

7. Zheng Z, Li YN, Jia S, Zhu M, Cao L, Tao M, Jiang J, Zhan S, Chen Y, Gao PJ, Hu W, Wang Y*, Shao C*, Shi Y*. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nat Commun. 2021 Oct 27;12(1):6202. doi: 10.1038/s41467-021-26460-z. PMID: 34707103; PMCID: PMC8551331.

8. Hang Y, Ma X, Liu C, Li S, Zhang S, Feng R, Shang Q, Liu Q, Ding Z, Zhang X, Yu L, Lu Q*, Shao C*, Chen H*, Shi Y, He J, Kaplan DL. Blastocyst-Inspired Hydrogels to Maintain Undifferentiation of Mouse Embryonic Stem Cells. ACS Nano. 2021 Sep 28;15(9):14162-14173. doi: 10.1021/acsnano.0c10468. Epub 2021 Sep 13. PMID: 34516077.

9. Li X, Su X, Liu R, Pan Y, Fang J, Cao L, Feng C, Shang Q, Chen Y, Shao C*, Shi Y*. HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression. Oncogene. 2021 Mar;40(10):1836-1850. doi: 10.1038/s41388-020-01636-x. Epub 2021 Feb 9. PMID: 33564072; PMCID: PMC7946638.

10. Liu R, Li X, Ma H, Yang Q, Shang Q, Song L, Zheng Z, Zhang S, Pan Y, Huang P, Fang J, Li Y, Liu Z, Cao L, Feng C, Gong Z, Chen Y, Wang Y, Melino G, Shao C*, Shi Y*. Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy. Free Radic Biol Med. 2020 Dec;161:339-350. doi: 10.1016/j.freeradbiomed.2020.10.029. Epub 2020 Oct 24. PMID: 33122005.

11. Xu L, Wu T, Lu S, Hao X, Qin J, Wang J, Zhang X, Liu Q, Kong B, Gong Y, Liu Z, Shao C*. Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells. Redox Biol. 2020 Sep;36:101604. doi: 10.1016/j.redox.2020.101604. Epub 2020 Jun 8. PMID: 32554304; PMCID: PMC7303666.

12. Li X, Liu R, Su X, Pan Y, Han X*, Shao C*, Shi Y*. Harnessing tumor-associated macrophages as aids for cancer immunotherapy. Mol Cancer. 2019 Dec 5;18(1):177. doi: 10.1186/s12943-019-1102-3. PMID: 31805946; PMCID: PMC6894344.